In Issue 160, it is first mentioned by Arthur Read that Buster and Ladonna are a couple. Buster immediately complains about how Ladonna has been planning a joint trip to Louisiana, and he remarks "I gotta ditch her." Soon after, Ladonna forces Buster to come to her house for dinner, despite Buster claiming that he'd already been over every night that week.
Buster and Ladonna are shown to be partners is science class during Issue 167. Ladonna once again chides Buster about their trip to Louisiana, to which Buster repeatedly shoots down.
In Issue 172, Buster and Ladonna continue to argue about the Louisiana trip. Ladonna ignores Buster's claim that he "has plans," to which Buster angrily says "you just don't listen." To the horror of Buster and the surrounding bystanders, Ladonna suddenly announces that she has already told her family she and Buster were married. Furious, Buster immediately breaks up with her. Ladonna is later showing crying hysterically with her mother.